Research Areas
Research Areas by topic:
Cellular and Molecular Biology
Disease Surveillance
Drug Discovery, Vaccine Research and Diagnostic Development
Genomics and Bioinformatics
Host Defense and Inflammation
Mosquito/Parasite Interactions
Cellular and Molecular Biology
| PI | Research Description |
| Branch, Oralee | P. falciparum erythrocyte invasion |
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Pneumocystis and its effects on polyamine and Adomet metabolism |
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Proteolytic processing of circumsporozoite Plasmodium protein |
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Density dependent growth of P. falciparum |
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Protein and gene expression levels that induce cyst formation in Entamoeba spp. |
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Immunobiology of Plasmodium |
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Activation of Plasmodium sporozoites preceding infection of liver hepatocytes |
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Role of proteases in hepatocyte invasion by sporozoite |
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Intracellular second messengers and the induction of sporozoite motility |
| PI | Research Description |
| Consequences of anemia during pregnancy on the outcome of children (with Beninese and French collaborators) | |
| P. falciparum and P. vivax co-transmission dynamics | |
| Genetic diversity, population structure and evolution of T. vaginalis and P. vivax | |
| Molecular and genetic epidemiology of P. falciparum malaria | |
| Genomic approaches to monitor and evaluate malaria eradication |
Drug Discovery, Vaccine Research and Diagnostic Development
| PI | Research Description |
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P. vivax vaccine candidate antigen genetic diversity (Peruvian cohort study) |
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Novel diagnostics for trichomonads and P. vivax; antimalarial drug resistance |
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New compounds for Pneumocystis pneumonia treatment |
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Inhibition of cysteine proteases in preerythrocytic and erythrocytic stages of Plasmodium |
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Genomic models of malaria transmission |
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Drug candidate screening for inhibition of Entamoeba spp. Excystment |
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(with Nardin) Imaging effector functions of human Plasmodium-specific cytotoxic CD4+ T cells |
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Rational design of adjuvants and delivery systems for malaria subunit vaccines |
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High throughput screening of intracellular Trypanosoma cruzi |
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Screening protease inhibitor libraries against the CSP protease and designing inhibitory anitbodies targeting the CSP cleavage site |
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Biology of mosquito-sporozoite-host interactions |
| PI | Research Description |
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Development of effective immune responses and malaria genetic diversity |
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Comparative genomics of parasitic protists, including Plasmodium, Trichomonas and Cryptosporidium |
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Population genetics of var genes underlying antigenic variation |
| PI | Research Description |
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Effect of transmission dynamics on malaria immunity development; (with Rodriguez) Inflammatory response and new pathways; Immunology memory and immune responses throughout successive P. falciparum and P. vivax infections |
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Immunobiology and pathogenesis of Plasmodium infections |
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Neutralizing antibody targets and CD4+ T cell induction of optimal humoral and cellular immunity; (with Sinnis) Molecular basis of antibody neutralization of sporozoite infection; (with Frevert) CD4+ T cell and dendritic cell interaction during induction and effector phase of host immune response |
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Trypanosome lytic factor and its role in innate immunity |
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Uric acid as a mediator of P. falciparum-induced inflammation; Role of dendritic cell subpopulations in the development of malaria |
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Host response of sporozoites in skin |
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Role of immediate cutaneous hypersensitivity against mosquito bites in modulation of delivery of sporozoites |
Mosquito/Parasite Interactions
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PI |
Research Description |
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Interactions of malaria-causing species in infection of same human-host populations |
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(with Vanderberg) Intravital microscopy study anopheline mosquito transmission of Plasmodium sporozoites into mice skin |
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Molecular interactions between sporozoites and their mosquito hosts |
