Selected Publications

The following is a list of publications (including journals and book chapters) by department faculty within the last 2 years.  The publications are listed alphabetically by faculty member.

Oralee Branch

Parekh FK, Hernandez JN, Krogstad DJ, Casapia WM, Branch OH. Prevalence and risk of P. falciparum and P. vivax malaria among pregnant women living in the hypoendemic communities of the Peruvian Amazon. Am J Trop Med Hyg 2007 Sept, 77(3): 451-7.

Chenet SM, Branch OH, Escalante AA, Lucas CM, Bacon DJ. Genetic diversity of vaccine candidate antigens in Plasmodium falciparum isolates from the Amazon basin of Peru. Malaria Journal 2008, 7:93.

Torres KJ, Clark EH, Hernandez JN, Soto-Cornejo KE, Gamboa D, Branch OH. Antibody response dynamics to the Plasmodium falciparum conserved vaccine candidate antigen, merozoite surface protein-1 C-terminal 19kD (MSP1-19kD), in Peruvians exposed to hypoendemic malaria transmission. Malaria Journal 2008, 9;7:173.

Jane Carlton

Jane M Carlton. Towards a malaria haplotype map. Nature Genetics. 2007 Jan:39(1);5-6.

Jane M. Carlton, Robert P. Hirt, Joana C. Silva, Arthur L. Delcher, Michael Schatz, et al. Draft genome sequence of the sexually-transmitted pathogen Trichomonas vaginalis. Science. 2007 Jan 12:315(5809);207-12.

Imwong M, Snounou G, Pukrittayakamee S, Tanomsing N, Kim JR, Nandy A, Guthmann JP, Nosten F, Carlton J, Looareesuwan S, Nair S, Sundimack D, Day NP, Anderson TJ, White NJ. Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. J Infect Dis. 2007 Apr 1;195(7):927-33.

Imwong M, Nair S, Pukrittayakamee S, Sudimack D, Williams JT, Mayxay M, Newton PN, Kim JR, Nandy A, Osorio L, Carlton JM, White NJ, Day NP, Anderson TJ. Contrasting genetic structure in Plasmodium vivax populations from Asia and South America. Int J Parasitol. 2007 Jul;37:1013-22. Epub 2007 Mar 12.

Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, Winzeler EA. Evidence-Based Annotation of the Malaria Parasite's Genome Using Comparative Expression Profiling. PLoS ONE. 2008 Feb 13;3(2):e1570.

Joy DA, Gonzalez-Ceron L, Carlton JM, Gueye A, Fay M, McCutchan TF, Su XZ. Local Adaptation and Vector-Mediated Population Structure in Plasmodium vivax Malaria. Mol Biol Evol. 2008 Jun;25(6):1245-52.

Joshi H, Prajapati SK, Verma A, Kang'a S, Carlton JM. Plasmodium vivax in India. Trends Parasitol. 2008 May;24(5):228-35.

Aurrecoechea C, Brestelli J, Brunk BP, Carlton JM et al. GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis. Nucleic Acids Res. 2008 Sep 29. [Epub ahead of print].

Carlton JM, Adams JH et al. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature. 2008 Oct 9;455(7214):757-63.

Bozdech Z, Mok S, Hu G, Imwong M, Jaidee A, Russell B, Ginsburg H, Nosten F, Day NP, White NJ, Carlton JM, Preiser PR. The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. Proc Natl Acad Sci USA. 2008 Oct 13. [Epub ahead of print].

Carlton JM, Escalante A, Neafsey D, Volkman SK. Comparative evolutionary genomics of human malaria parasites. Trends in Parasitology (Accepted)

Allen Clarkson

Baer K, Roosevelt M, Van Rooijen N, Clarkson Jr AB and Frevert U. Kupffer cells are obligatory for Plasmodium sporozoite infection of the liver. Cell Microbiol. 2007 Feb:9(12);397-412.

Moncada CA, Clarkson A, Perez-Leal O, Merali S. 2008. “Mechanism and tissue specificity of nicotine-mediated lung S-adenosylmethionine reduction.” J Biol Chem. 283(12):7690-6.

Karen Day

Volkman SK, Lozovsky E, Barry AE, Bedford T, Bethke L, Myrick A, Day KP, Hartl DL, Wirth DF, Sawyer SA. Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum. Gene 2007 Jan 31:387(1-2);1-6.

Imrie H, Fowkes FJI, Michon P, Tavul L, Reeder J, Day KP. Low prevalence of an acute phase response in asymptomatic children from a malaria endemic area of Papua New Guinea. Am J Trop Med Hyg. 2007 Feb:76(2);280-4.

Barry AE, Leliwa-Sytek A, Tavul L, Imrie H, Migot-Nabias F, McVean GAV, Day KP. Population genomics of the immune evasion (var) genes of Plasmodium falciparum. PLoS Pathogens 2007 Mar 13;3(3):e34

Wood MJ, Cosgrove CL, Wilkin TA, Knowles SC, Day KP, and Sheldon BC. Within-population variation in prevalence and lineage distribution of avian malaria in blue tits, Cyanistes caeruleus. Mol Ecol. 2007 Aug;16:3263-73.

Hume JC, Tunnicliff M, Ranford-Cartwright LC, and KP Day.  Susceptibility of Anopheles gambiae and Anopheles stephensi to tropical isolates of Plasmodium falciparum.  Malar J. 2007 Oct 24; 6:139.

Fowkes FJ, Michon P, Pilling L, Ripley RM, Tavul L, Imrie HJ, Woods CM, Mgone CS, Luty AJ, and KP Day.  Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea.  Malar J.  2008 Jan 3;7:1.

Cosgrove CL, Wood MJ, Day KP, and BC Sheldon.  Seasonal variation in Plasmodium prevalence in a population of blue tits Cyanistes caeruleus.  J Anim Ecol. 2008 Feb 25 [Epub ahead of print].

Orengo JM, Evans JE, Bettiol E, Leliwa-Sytek A, Day K and Rodriguez A. Plasmodium-induced inflammation by uric acid. PLoS Pathogens. 2008 Mar 7; 4(3): e1000013.

Fowkes FJ, Allen SJ, Allen A, Alpers MP, Weatherall DJ, Day KP. Increased microerythrocytic count associated with α+ - thalassemia homozygosity reduces the risk of severe malarial anemia. PLOS Medicine. 2008 Mar 18; 5(3):e56.

Dan Eichinger

Ehrenkaufer GM, Haque R, Hackney JA, Eichinger D, Singh U. Identification of developmentally regulated genes in Entamoeba histolytica: insights into mechanisms of stage conversion in a protozoan parasite. Cell Microbiol. 2007 Jan 22 [ePub ahead of print].

Teixeira, M.C.A., Oliveira, G.G.S., Silvany, M.A., Alcantara-Nueves, N.M., Soares, M.B.P., Ribeiro-dos-Santos, R., Jeronimo, S.M.B., Costa, C.H., dos-Santos, W.L.C., Eichinger, D., Pontes-de-Carvalho, L. 2006. A strategy for identifying serodiagnostically relevant antigens of Leishmania or other pathogens in genetic libraries. Biologicals. 2007 35(1):51-54.

Ehrenkaufer GM, Haque R, Hackney JA, Eichinger DJ, Singh U.  Identification of developmentally regulated genes in Entamoeba histolytica: insights into mechanisms of stage conversion in a protozoan parasite. Cell Microbiol. 2007 Jun;9(6):1426-44. Epub 2007 Jan 22.

Ehrenkaufer GM, Eichinger DJ, Singh U.  Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica.  BMC Genomics. 2007 Jul 5;8:216.

Turner N, Eichinger D. Entamoeba invadens: the requirement for galactose ligands during encystment. Exp Parasitol. 2007 Aug 116(4);467-474.

Eichinger, D. 2007. Entamoeba. In: Parasitology. Edited by A. Satoskar, G. Simon, P. Hotez and M. Tsuji, Landes Bioscience, Austin, Texas. (In press).

Brewer, L.A., M.C. Denver, M. Whitney and D. Eichinger. 2007. Analysis of commercial ELISA kits for the detection of reptile amebiasis. J Zoo Wildlife Med. (In press).

Byers J, Eichinger D.  Acetylation of the Entamoeba histone H4 N-terminal domain is influenced by short-chain fatty acids that enter trophozoites in a pH-dependent manner. Int J Parasitol. 2008 Jan;38(1):57-64. Epub 2007 Jul 12.

Ute Frevert

Baer K, Roosevelt M, Van Rooijen N, Clarkson Jr AB and Frevert U. Kupffer cells are obligatory for Plasmodium. Cell Microbiol. sporozoite infection of the liver. 2007 Feb:9(12);397-412.

Baer K, Klotz, Kappe SH, Schneider T, Frevert U. Resease of hepatic Plasmodium yoelii merozoites into the pulmonary microvasculature. PLoS Pathogens. 2007 Nov 3(11); e171.

Usynin I, Klotz C, Frevert U. Malaria circumsporozoite protein inhibits the respiratory burst in Kupffer cells. Cell Microbiol. 2007 Nov 9(11);2610-2628.

Frevert U, Usynin I, Baer K, and Klotz C. Penetrating Biological Barriers. Liver: Plasmodium Sporozoite Passage across the Sinusoidal Cell Layer. In: Molecular Mechanisms of Parasite Invasion. Soldati, D. & Burleigh, B. (eds). Landis Bioscience, Georgetown. In press.

Frevert U, Spaeth G, Yee H. Exoerythrocyte development of Plasmodium gallinaceum in the White Leghorn chicken. Int J Parasitol. 2008 May; 38(6): 655-72.

Frevert U, Usynin I, Baer K, Klotz C.  Plasmodium sporozoite passage across the sinusoidal cell layer.  Subcell Biochem. 2008;47:182-97. Review.

Klotz C, Frevert U. (2008) Plasmodium yoelii sporozoites modulate cytokine profile and induce apoptosis in murine Kupffer cells. Int J Parasitol. Jul 9. [Epub ahead of print]

Frevert U, Moreno A, Calvo-Calle JM, Klotz C, Nardin E. (2008) Imaging effector functions of human cytotoxic CD4+ T cells specific for Plasmodium falciparum circumsporozoite protein. Int J Parasitol. Aug 6. [Epub ahead of print]

Frevert U & Nardin E. (2008) Cellular effector mechanisms against Plasmodium liver stages. Cell Microbiol. 10(10):1956-67.

Elizabeth Nardin

Gregson AL, Oliveira G, Othoro C, Calvo-Calle JM, Thorton GB, Nardin E, Edelman R. Phase I Trial of an Alhydrogel Adjuvanted Hepatitis B Core Virus-Like Particle Containing Epitopes of Plasmodium falciparum Circumsporozoite Protein.  PLoS ONE. 2008 Feb 6;3(2):e1556.

Oliveira GA, Kumar KA, Calvo-Calle JM, Othoro C, Altszuler D, Nussenzweig V, Nardin EH.  Class II-restricted protective immunity induced by malaria sporozoites. Infect Immun. 2008 Mar;76(3):1200-6.

Frevert U & Nardin E. (2008) Cellular effector mechanisms against Plasmodium liver stages. Cell Microbiol. In press.

Frevert, U., Moreno, A., Calvo-Calle, M. Klotz, C and Nardin, E. (2008) Human Cytotoxic CD4+ T cells specific for Plasmodium falciparum Circumsporozoite Protein.  Int J Parasitol. In press.

Othoro, C., Johnston, D., Lee, R. Bystryn, J-C and Nardin, E. (2008) Immunogenicity of malaria CS peptide vaccines using a topical adjuvant containing a potent synthetic TLR agonist, Imiquimod. Infection and Immunity. In press.

Jayne Raper

Molina-Portela MP, Samanovic M,  Raper J.  Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model. J Exp Med. 2008 Jul 7. [Epub ahead of print].

Ana Rodriguez

Takeshi Ono, Takushi Tadakuma and Ana Rodriguez. Plasmodium yoelii constitutively expressing GFP throughout the life cycle. Experimental Parasitology. 2007 Mar:115(3);310-13, e-pub Oct 2006.

Ocana-Morgner C, Wong KA, Lega F, Dotor J, Borras-Cuesta F, Rodriguez A. Role of TGF-b and PGE2 in T-cell responses during P. yoelii infection. European J Immunol. 2007 June 37(6);1562-74.

Carapau D, Kruhofer M, Chatalbash A, Orengo JM, Mota MM and Rodriguez A. Transcriptome profile of dendritic cells during malaria: cAMP regulation of IL-6. Cell Microbio. 2007 July 9(7):1738-52.

Hafalla, JCR, Rai, U, Bernal-Rubio, D, Rodriguez, A and F Zavala. Efficient development of Plasmodium liver stage-specific memory CD8+ T cells during the course of blood stage malaria infection. Journal of Infectious Diseases. 2007 Dec 15;196(12):1827-35.

Wong KA and A Rodriguez. Plasmodium infection and endotoxic shock induce the expansion of regulatory dendritic cells. Journal of Immunology. 2008 Jan 15; 180(2):716-26.

Mota MM, Rodriguez A.  New pieces for the malaria liver stage puzzle: where will they fit? Cell Host Microbe. 2008 Feb 14; 3(2):63-5.

Yanow SK, Purcell LA, Pradel G, Sato A, Rodriguez A, Lee M, and Spithill TW. (2008). Potent antimalarial and transmission-blocking activities of a novel DNA binding agent. Journal of Infectious Diseases. 2008 Feb 15; 197(4):527-534.

Ono T, Cabrita-Santos L, Leitao R, Bettiol E, Purcell LA, Diaz-Pulido O, Andrews LB, Tadakuma T, Bhanot P, Mota MM and Rodriguez A.  Adenylyl cyclase A and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection. PLoS Pathogens. 2008 Feb 29; 4(2): e1000008.

Purcell LA, Yanow SK, Lee M, Spithill TW, and A Rodriguez. Chemical attenuation of Plasmodium berghei sporozoites induces sterile immunity in mice. Infection and Immunity. 2008 Mar; 76(3):1193-9.

Orengo JM, Evans JE, Bettiol E, Leliwa-Sytek A, Day K and Rodriguez A. Plasmodium-induced inflammation by uric acid. PLoS Pathogens. 2008 Mar 7; 4(3): e1000013.

Ocaña-Morgner C, Wong KA and Rodriguez A. (2008). Interactions between dendritic cells and CD4+ T cells during Plasmodium infection. Malaria Journal 2008 May 21;7:88.

Photini Sinnis

Yamauchi LM, Coppi A, Snounou G and Sinnis P. Plasmodium sporozoites trickle out of the injection site. Cell Microbio. 2007 9(5):1215-1222.

Bhandari R, Janos DP and Sinnis P. Furuncular myiasis in a returning traveler caused by Dermatobia hominis. Am J Trop Med Hyg. 2007 Mar;76:598-599.

Sinnis P, Coppi A, Toida T, Toyoda H,  Kinoshita-Toyoda A, Xie J, Kemp MM and Linhardt RJ. Mosquito heparan sulfate and its potential role in malaria infection and transmission. J Biol Chem. 2007 Aug 282: 25376-84.

Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA and Dobson CB.  Apolipoprotein E-derived anti-microbial peptide analogues with altered membrane affinity and increased potency and breadth of activity. FEBS Journal. 2007 Sept 274:4511-25.

Sinnis P and Coppi A. A Long and Winding Road: The Plasmodium Sporozoite's Journey in the Mammalian Host. Parasitology International. 2007 Sept 56:171-178.

Coppi A., Tewari R., Bishop J.R., Bennett B.L., Lawrence R., Esko J., Billker O. and Sinnis P. Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade cells. Cell Host & Microbe. 2007 Nov 2:316-327.

Grüner A.C., Mauduit M., Tewari R., Romero J.F., Depinay N., Kayibanda M., Lallemand E., Chavatte J.M., Crisanti A., Sinnis P., Mazier D., Corradin G., Snounou G. and Rénia L. Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. PLoS One, 2007 Dec 26: 2:e1371.

Sinnis P.  Giardia. In: Parasitology. A. Satoskar, G. Simon, P. Hotez and M. Tsuji (eds). Landes Bioscience, Austin Texas. In Press.

Hobbs C.V., Voza T., Coppi A., Marsh K., Borkowsky W. and Sinnis P. (2008) HIV protease inhibitors affect development of pre-erythrocytict stage Plasmodium. J Infect Dis, In Press.

Moreira C.K., Templeton T.J., Lavazec C., Hayward R.E., Hobbs C.V., Kroeze H., Janse C.J., Waters A.P., Sinnis P. and Coppi A. (2008) The Plasmodium TRAP/MIC2 family member, TRAP-Like Protein (TLP), is involved in tissue traversal by sporozoites. Cell Microbiol, 2008 Jul;10(7):1505-16.

Sinnis P and Ernst JD.  Co-opting the host HO-1 pathway in tuberculosis and malaria.  Cell Host Microbe. 2008 May 15;3(5):277-9.

Sinnis P and Zavala F.  The skin stage of malaria infection: biology and relevance to the malaria vaccine effort.  Future Microbiol. 2008 Jun;3:275-8. Review.

Gissot M, Ting LM, Daly TM, Bergman LW, Sinnis P, K Kim. High mobility group protein HMGB2 is a critical regulator of Plasmodium oocyst development. J Biol Chem. 2008 Jun 20;283(25):17030-8.

Ting L-M, Gissot M, Coppi A, Sinnis P and Kim K. (2008) Attenuated Plasmodium yoelii Lacking Purine Nucleoside Phosphorylase Confer Protective Immunity. Nat Med.14:954-8, 2008.

Vaccination with live P. yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage. Belnoue E., Voza T., Costa F.T.M., Gruner A.C., Mauduit M., Rosa D.S., Depinay N., Kayibanda M., Vigario A.M., Mazier D., Snounou G., Sinnis P. and Renia L.  Journal of Immunology, In Press.

Jerome Vanderberg

Vanderberg, J.P. and U. Frevert. 2004. Intravital microscopy demonstrating antibody-mediated immobilisation of Plasmodium berghei sporozoites injected into skin by mosquitoes. Int. J. Parasitol. 34: 991-996. PDF

Kebaier, C. and J. P. Vanderberg. 2006. Re-ingestion of Plasmodium berghei sporozoites after delivery into the host by mosquitoes. Am. J. Trop. Med. Hyg. 75: 1200-1204.

Vanderberg, JP et al. Assessment of antibody protection against malaria sporozoites must be done by mosquito injection of sporozoites. Am J Path. 2007 Oct, 171: 1405. PDF

Jin Y, C Kebaier, and J P Vanderberg. Direct microscopic quantification of transmission dynamics of Plasmodium sporozoites from mosquitoes to mice. Infect Immun. 2007 Nov 75(11): 5532-5539. PDF

Vanderberg, JP. Reflections on early malaria vaccine studies, the first successful human malaria vaccination, and beyond. Vaccine. 2008 27:2-9. Word format

Kebaier, C., T. Voza and J. P. Vanderberg. 2009. Kinetics of mosquito-injected Plasmodium berghei sporozoites in immunized vs. non-immunized mice. PLoS Pathog 5, e1000399. http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000399

Kebaier, C., and J. P. Vanderberg. 2009. Initiation of Plasmodium sporozoite motility by albumin is associated with induction of intracellular signaling. Int. J. Parasitol. Online doi:10.1016/j.ijpara.2009.06.011